Continuous operation
Enables fact processing time, with reliable, predictable steady-state operation. In fact, CultureOne processing times are often less then or equal to only four hours.
Why batch is out, and continuous is in
A separation technique which operates continually results in a steady state condition. The result is a more stable, predictable process performance, without the process upsets associated with batch. A continuous approach = A simplified operation.
Exceptional yield, recover more
We know you need to recover as many valuable modules as possible, regardless of cell densities. And CultureOne is especially well-suited for high titer processes, providing the highest biomass concentrations possible, with continuous concentrate output.
The secret behind increased yield
The enemy of cell lysis and ultimately lower yield is shear thinning. Understanding the shear thinning properties of a cell culture is what makes continuous separation possible. And once we can treat the biomass as a liquid, then CultureOne with patented TopStreamTM technology provides those higher concentrations and yields.
Minimizes additional lysis
Tired of dealing with molecule lysis? CultureOne is equipped with fully hermetic technology, which helps to keep cells intact.
Why a hermetic centrifuge is so important
A hermetic design starts with the inlet and outlet, as they impact velocity of material. A hermetic, bottom-fed design is ideal for all cell cultures, as the hermetic inlet spreads the shear forces over a greater area, providing very gentle acceleration of fermentation broth.
