From greater flexibility to shorten time to market, and increased assurance of patient safety - several factors have driven the growing transition to single-use processing in the biopharma industry. And CultureOne delivers dependable, high-quality performance.
As the market’s first proven, premium separator for single-use biopharmaceutical processing, processors can expect gentle treatment, increased yield and maximum separation efficiency - creating new possibilities for processing cell-culture-based fermentations.
Are increased molecule densities making it difficult? Do higher densities limit yields and bottleneck your operations? CultureOne reduces the losses, and helps eliminate ballroom bottlenecks. There will also be no need for filter acids or flocculants - saving additional downstream process steps and time.
Did you know CultureOne can continuously concentrate biomass or molecule cultures up to 95% v/v - and is completely repeatable? And, it's 100% single-use. After all, your scientists and bio-engineers don't have the time for endless validation or cleaning steps.
A separation technique which operates continually results in a steady state condition. The result is a more stable, predictable process performance, without the process upsets associated with batch. A continuous approach = A simplified operation.
The enemy of cell lysis and ultimately lower yield is shear thinning. Understanding the shear thinning properties of a cell culture is what makes continuous separation possible. And once we can treat the biomass as a liquid, then CultureOne with patented TopStreamTM technology provides those higher concentrations and yields.
A hermetic design starts with the inlet and outlet, as they impact velocity of material. A hermetic, bottom-fed design is ideal for all cell cultures, as the hermetic inlet spreads the shear forces over a greater area, providing very gentle acceleration of fermentation broth.